Lot numbers can be found on the outside label of a product:
6-Chloro-3-methoxy-2-methylpyridine
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CAS No. 129692-13-3
- Cat. No. CS-0577217
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 129692-13-3
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General Information
- CAS No. 129692-13-3
- Cat. No. CS-0577217
- Purity ≥98%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₈ClNO
- Molecular Weight 157.60
- Synonym(s) None
- SMILES CC1=C(C=CC(=N1)Cl)OC
Description
6-Chloro-3-methoxy-2-methylpyridine features a trifunctional pyridine core enabling selective coupling in medicinal chemistry. The chlorine at C6 facilitates palladium-catalyzed cross-coupling, while the methoxy group enhances solubility and modulates electronic properties. The methyl substituent at C2 provides steric and electronic control, improving reaction site selectivity. This compound serves as a key scaffold for kinase inhibitors and bioactive heterocycles under standard bench conditions.
Application
6-Chloro-3-methoxy-2-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chloro group exhibits high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the methoxy and methyl substituents provide favorable electronic modulation and steric control. The compound demonstrates excellent bench stability and compatibility with standard purification methods, facilitating its use in multi-step synthesis of pharmaceutical intermediates and functionalized heterocycles.
Synthesis
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Route1
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In-stock
26395-26-6 - ~%
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In-stock
129692-13-3
References
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Heterocycles, , vol. 30, # 2 p. 875 - 884
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Route2
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In-stock
52605-96-6 - ~%
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In-stock
129692-13-3
References
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Heterocycles, , vol. 30, # 2 p. 875 - 884
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Route3
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In-stock
20928-63-6 - ~%
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In-stock
129692-13-3
References
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Heterocycles, , vol. 30, # 2 p. 875 - 884
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 22.12
- LogP 2.05202
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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