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CS-W001157 4
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7-Chloro-1H-indazole-3-carboxylic acid

  • CAS No. 129295-32-5

  • Cat. No. CS-0018915
  • Purity≥98%
  • MDL No.MFCD05663990

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1H-indazole-3-carboxylic acid|CS-0018915

Structure of 129295-32-5

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General Information

  • CAS No. 129295-32-5
  • Cat. No. CS-0018915
  • Purity ≥98%
  • MDL No. MFCD05663990
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O₂
  • Molecular Weight 196.59
  • Synonym(s) 7-Chloroindazole-3-carboxylic acid
  • SMILES O=C(C1=NNC2=C1C=CC=C2Cl)O

Description

7-Chloro-1H-indazole-3-carboxylic acid is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 7-position and a carboxylic acid group at the 3-position. This combination imparts enhanced electron-withdrawing character and improved solubility in polar solvents, enabling direct incorporation into bioactive molecule synthesis.

Application

7-Chloro-1H-indazole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling reactions. Its carboxylic acid functionality facilitates amide and ester formation under mild conditions, while the chlorinated indazole core provides enhanced metabolic stability and π-stacking potential. Bench-stable and readily purified by recrystallization, it functions reliably in peptide-like conjugations and scaffold diversification for drug discovery applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.9145
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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