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4-Benzyloxybenzhydrazide

  • CAS No. 128958-65-6

  • Cat. No. CS-0204464
  • Purity≥98%
  • MDL No.MFCD00564772

*For research and further manufacturing use only, not for direct human use.

4-Benzyloxybenzhydrazide|CS-0204464

Structure of 128958-65-6

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General Information

  • CAS No. 128958-65-6
  • Cat. No. CS-0204464
  • Purity ≥98%
  • MDL No. MFCD00564772
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄N₂O₂
  • Molecular Weight 242.27
  • Synonym(s) 4-(Benzyloxy)benzohydrazide
  • SMILES O=C(NN)C1=CC=C(OCC=2C=CC=CC2)C=C1

Description

4-Benzyloxybenzhydrazide features a benzhydrazide scaffold linked to a para-benzyloxy aromatic group, delivering enhanced solubility and stability in polar solvents. This structural motif enables direct incorporation into hydrazone-based conjugation strategies and serves as a key intermediate for bioconjugates requiring site-specific labeling under mild conditions.

Application

4-Benzyloxybenzhydrazide serves as a versatile building block in synthetic organic chemistry, enabling the construction of heterocyclic scaffolds through condensation and cyclization reactions. Its benzyloxy and hydrazide functionalities offer orthogonal reactivity, facilitating selective transformations under mild conditions. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 36, # 9 p. 1157 - 1167
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 11, # 7 p. 1381 - 1387
  • Route3
    • Ethyl 4-hydroxybenzoate Erlotinib Impurity|CS-0167068
      120-47-8
    • ~%
    • In-stock
      4-Benzyloxybenzhydrazide|CS-0204464
      128958-65-6

    References

    • Journal of Medicinal Chemistry, , vol. 36, # 9 p. 1157 - 1167

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.8691
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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