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Structure of 1289114-66-4
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3-Amino-5-fluoropicolinaldehyde features a strategically positioned amino group and fluorine atom on the picolinaldehyde scaffold, enabling enhanced reactivity in nucleophilic addition processes. The electron-donating amine and electron-withdrawing fluorine create a polarized framework ideal for coupling reactions. This bench-stable derivative facilitates efficient synthesis of functionalized heterocycles and bioactive scaffolds under standard conditions.
3-Amino-5-fluoropicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via condensation and cyclization reactions. Its ortho-amino and aldehyde functionalities exhibit complementary reactivity, facilitating rapid access to substituted pyridines and fused ring systems. The fluorine substituent enhances metabolic stability and modulates electronic properties, while the aldehyde group allows for facile derivatization through imine formation or reductive amination. Bench-stable and compatible with standard synthetic workflows, it functions as a key intermediate in API development and target-oriented synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: