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CS-W001157 4
Total: USD 88.00

3-Amino-5-fluoropicolinaldehyde

  • CAS No. 1289114-66-4

  • Cat. No. CS-0198904
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Amino-5-fluoropicolinaldehyde|CS-0198904

Structure of 1289114-66-4

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Description

3-Amino-5-fluoropicolinaldehyde features a strategically positioned amino group and fluorine atom on the picolinaldehyde scaffold, enabling enhanced reactivity in nucleophilic addition processes. The electron-donating amine and electron-withdrawing fluorine create a polarized framework ideal for coupling reactions. This bench-stable derivative facilitates efficient synthesis of functionalized heterocycles and bioactive scaffolds under standard conditions.

Application

3-Amino-5-fluoropicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via condensation and cyclization reactions. Its ortho-amino and aldehyde functionalities exhibit complementary reactivity, facilitating rapid access to substituted pyridines and fused ring systems. The fluorine substituent enhances metabolic stability and modulates electronic properties, while the aldehyde group allows for facile derivatization through imine formation or reductive amination. Bench-stable and compatible with standard synthetic workflows, it functions as a key intermediate in API development and target-oriented synthesis.

General Information

  • CAS No. 1289114-66-4
  • Cat. No. CS-0198904
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O
  • Molecular Weight 140.12
  • Synonym(s) 3-aMino-5-fluoropyridine-2-carbaldehyde
  • SMILES O=CC1=NC=C(F)C=C1N

Computational Chemistry Data

  • TPSA   55.98
  • LogP   0.6154
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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