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CS-W001157 4
Total: USD 88.00

2-Fluoro-3-formylbenzoic acid

  • CAS No. 1289043-16-8

  • Cat. No. CS-0095020
  • Purity≥96%
  • MDL No.MFCD20526383

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-formylbenzoic acid|CS-0095020

Structure of 1289043-16-8

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General Information

  • CAS No. 1289043-16-8
  • Cat. No. CS-0095020
  • Purity ≥96%
  • MDL No. MFCD20526383
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅FO₃
  • Molecular Weight 168.12
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=CC(C=O)=C1F

Description

2-Fluoro-3-formylbenzoic acid features a strategically positioned formyl group adjacent to a fluorinated benzene ring, enabling direct integration into diverse synthetic scaffolds. This electron-deficient aryl aldehyde pairs readily with nucleophiles in condensation reactions, offering efficient access to functionalized heterocycles and bioactive intermediates under standard conditions.

Application

2-Fluoro-3-formylbenzoic acid serves as a versatile bifunctional building block in medicinal chemistry, enabling direct incorporation of both formyl and carboxylic acid functionalities into complex scaffolds. Its ortho-fluoro substituent enhances electrophilicity at the formyl group and facilitates downstream derivatization via nucleophilic addition or reductive amination. The compound exhibits good bench stability and is compatible with standard coupling and protection protocols, supporting efficient synthesis of heterocyclic systems and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.3364
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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