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CS-W001157 4
Total: USD 88.00

4-Amino-5-bromonicotinaldehyde

  • CAS No. 1289001-34-8

  • Cat. No. CS-0063825
  • Molecule weight201.02
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Amino-5-bromonicotinaldehyde|CS-0063825

Structure of 1289001-34-8

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General Information

  • CAS No. 1289001-34-8
  • Cat. No. CS-0063825
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O
  • Molecular Weight 201.02
  • Synonym(s) None
  • SMILES O=CC1=C(N)C(Br)=CN=C1

Description

4-Amino-5-bromonicotinaldehyde features a strategically positioned aldehyde group flanked by electron-donating amino and halogen substituents, enabling direct incorporation into bioconjugation workflows. This bench-stable scaffold facilitates the synthesis of targeted probes and functionalized building blocks for medicinal chemistry applications.

Application

4-Amino-5-bromonicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine derivatives via palladium-catalyzed cross-coupling and condensation reactions. Its dual functionality—aldehyde and amino groups—facilitates efficient diversification through reductive amination, Schiff base formation, and further functionalization. Bench-stable and compatible with common protecting group strategies, it supports scalable synthesis of heterocyclic scaffolds relevant to drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   1.2388
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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