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CS-W001157 4
Total: USD 88.00

4-Bromo-3-cyclopropyl-5-methyl-1H-pyrazole

  • CAS No. 1287752-84-4

  • Cat. No. CS-0637622
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-cyclopropyl-5-methyl-1H-pyrazole|CS-0637622

Structure of 1287752-84-4

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General Information

  • CAS No. 1287752-84-4
  • Cat. No. CS-0637622
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BrN₂
  • Molecular Weight 201.06
  • Synonym(s) None
  • SMILES CC1=C(Br)C(C2CC2)=NN1

Description

4-Bromo-3-cyclopropyl-5-methyl-1H-pyrazole is a sterically defined heterocyclic scaffold featuring bromine and methyl substituents at strategic positions, enabling direct functionalization in cross-coupling reactions. The cyclopropyl group imparts conformational rigidity, while the pyrazole core offers tunable electronic properties for medicinal chemistry applications.

Application

4-Bromo-3-cyclopropyl-5-methyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromine handle. The cyclopropyl and methyl groups provide steric and electronic modulation, enhancing metabolic stability in target scaffolds. Its bench-stable solid form facilitates handling and purification, making it suitable for iterative synthesis of heterocyclic APIs and drug candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.35802
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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