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Tert-butyl 3-bromo-1H-pyrazolo[3,4-c]pyridine-1-carboxylate

  • CAS No. 1286755-24-5

  • Cat. No. CS-0508675
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 3-bromo-1H-pyrazolo[3,4-c]pyridine-1-carboxylate|CS-0508675

Structure of 1286755-24-5

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General Information

  • CAS No. 1286755-24-5
  • Cat. No. CS-0508675
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂BrN₃O₂
  • Molecular Weight 298.14
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)N1N=C(Br)C2=C1C=NC=C2

Description

Tert-butyl 3-bromo-1H-pyrazolo[3,4-c]pyridine-1-carboxylate is a bench-stable heterocyclic building block featuring a brominated pyrazolopyridine core. The tert-butyl ester group enhances solubility and stability, enabling efficient coupling in palladium-catalyzed transformations. This compound serves as a key intermediate for synthesizing bioactive molecules in medicinal chemistry.

Application

Tert-butyl 3-bromo-1H-pyrazolo[3,4-c]pyridine-1-carboxylate serves as a versatile building block for the synthesis of functionalized pyrazolopyridine scaffolds. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the tert-butyl ester group offers stability and facile deprotection under mild acidic conditions. This compound facilitates the construction of biologically relevant heterocycles with high efficiency and predictable reactivity in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   57.01
  • LogP   2.977
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   0

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