7-Hydroxy-(3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Name: 7-Hydroxy-(3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 128502-56-7
Cat. No. CS-W009083
Purity≥96%
MDL No.MFCD00144534

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

7-Hydroxy-(3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid|CS-W009083

Structure of 128502-56-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 128502-56-7
Cat. No. CS-W009083
Purity ≥96%
MDL No. MFCD00144534
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁NO₃
Molecular Weight None
Synonym(s) (S)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
SMILES O=C(O)[C@H](C1)NCC2=C1C=CC(O)=C2

Description

This tetrahydroisoquinoline derivative features a hydroxyl group at the 7-position and a carboxylic acid at C3, with stereochemistry defined at the 3S center. The scaffold integrates a phenolic moiety and a chiral carboxylic acid, enabling use in bioactive molecule synthesis. Bench-stable and moisture-tolerant, it serves as a key building block for alkaloid-inspired pharmaceuticals and chemical probes.

Application

7-Hydroxy-(3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid serves as a key chiral building block for the synthesis of bioactive isoquinoline derivatives. Its well-defined stereochemistry at C3 and orthogonal functional groups enable reliable derivatization via amide coupling, esterification, or electrophilic substitution. The molecule exhibits good bench stability and facilitates efficient purification, making it suitable for medicinal chemistry campaigns targeting CNS-active compounds and natural product analogs.

Synthesis

Route1
- 142335-40-8
- ~74%
- In-stock
  
  128502-56-7
References
- Verschueren; Toth; Tourwe; Lebl; Van Binst; Hruby Synthesis, 1992 , # 5 p. 458 - 460
Route2
- In-stock
  
  300-39-0
- ~%
- In-stock
  
  128502-56-7
References
- Synthesis, , # 5 p. 458 - 460

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 69.56
LogP 0.4911
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic heterocycle compounds Tetrahydroisoquinoline compounds

Key Words

128502-56-7 sigma128502-56-7 manufacturer128502-56-7 price128502-56-7 structure128502-56-7 SDSbuy 128502-56-7128502-56-7 supplier128502-56-7 uses128502-56-7 molecular weightprice of 128502-56-7128502-56-7 chemical name formula of 128502-56-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

7-Hydroxy-(3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

CAS No. 128502-56-7

Recommended Products