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Structure of 1284220-49-0
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5-(Difluoromethyl)-1H-pyrazol-3-amine features a difluoromethyl group appended to a pyrazole scaffold, imparting enhanced metabolic stability and modulated lipophilicity. This electron-deficient heterocycle integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.
5-(Difluoromethyl)-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a hydrogen-bonding pyrazole amine. Its functional group tolerance facilitates coupling reactions and downstream derivatization, while the scaffold exhibits favorable bench stability and ease of purification—ideal for rapid SAR exploration in drug discovery programs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: