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Structure of 1283717-58-7
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4-(Difluoromethyl)piperidine hydrochloride offers a fluorinated alkyl handle for medicinal chemistry optimization, combining enhanced metabolic stability with favorable physicochemical properties. This bench-stable derivative integrates readily into target-directed scaffolds, delivering improved membrane permeability and resistance to oxidative degradation in drug discovery campaigns.
4-(Difluoromethyl)piperidine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the introduction of a metabolically stable difluoromethyl group adjacent to a saturated nitrogen heterocycle. The difluoromethyl moiety imparts enhanced lipophilicity and metabolic resistance, while the piperidine core provides a versatile scaffold for further functionalization. This compound exhibits excellent bench stability, facilitates straightforward purification, and is compatible with standard coupling and transformation protocols in API synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: