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CS-W001157 4
Total: USD 88.00

4-(Difluoromethyl)piperidine hydrochloride

  • CAS No. 1283717-58-7

  • Cat. No. CS-W022014
  • Purity≥97%
  • MDL No.MFCD18711662

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethyl)piperidine hydrochloride|CS-W022014

Structure of 1283717-58-7

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General Information

  • CAS No. 1283717-58-7
  • Cat. No. CS-W022014
  • Purity ≥97%
  • MDL No. MFCD18711662
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClF₂N
  • Molecular Weight 171.62
  • Synonym(s) None
  • SMILES FC(C1CCNCC1)F.[H]Cl

Description

4-(Difluoromethyl)piperidine hydrochloride offers a fluorinated alkyl handle for medicinal chemistry optimization, combining enhanced metabolic stability with favorable physicochemical properties. This bench-stable derivative integrates readily into target-directed scaffolds, delivering improved membrane permeability and resistance to oxidative degradation in drug discovery campaigns.

Application

4-(Difluoromethyl)piperidine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the introduction of a metabolically stable difluoromethyl group adjacent to a saturated nitrogen heterocycle. The difluoromethyl moiety imparts enhanced lipophilicity and metabolic resistance, while the piperidine core provides a versatile scaffold for further functionalization. This compound exhibits excellent bench stability, facilitates straightforward purification, and is compatible with standard coupling and transformation protocols in API synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.6729
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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