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Total: USD 88.00

3-Chloro-5-methoxypicolinic acid

  • CAS No. 128073-09-6

  • Cat. No. CS-0186810
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-methoxypicolinic acid|CS-0186810

Structure of 128073-09-6

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Description

3-Chloro-5-methoxypicolinic acid features a strategically positioned chloro group and methoxy substituent on the picolinic acid scaffold, enhancing electronic modulation and metabolic stability. This combination improves binding affinity in targeted receptor interactions and supports efficient derivatization under standard coupling conditions.

Application

3-Chloro-5-methoxypicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of halogen and ester functionalities into bioactive heterocycles. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-coupling reactions, while the methoxy group offers orthogonal handle for subsequent derivatization. The compound exhibits excellent bench stability and compatibility with standard synthetic workflows, facilitating efficient access to complex scaffolds in API development.

General Information

  • CAS No. 128073-09-6
  • Cat. No. CS-0186810
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃
  • Molecular Weight 187.58
  • Synonym(s) 3-Chloro-5-Methoxy-2-pyridinecarboxylic acid
  • SMILES COC1=CC(=C(C(=O)O)N=C1)Cl

Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.4418
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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