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3-Chloro-5-methoxypicolinic acid

  • CAS No. 128073-09-6

  • Cat. No. CS-0186810
  • Molecule weight187.58
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-methoxypicolinic acid|CS-0186810

Structure of 128073-09-6

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General Information

  • CAS No. 128073-09-6
  • Cat. No. CS-0186810
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃
  • Molecular Weight 187.58
  • Synonym(s) 3-Chloro-5-Methoxy-2-pyridinecarboxylic acid
  • SMILES COC1=CC(=C(C(=O)O)N=C1)Cl

Description

3-Chloro-5-methoxypicolinic acid features a strategically positioned chloro group and methoxy substituent on the picolinic acid scaffold, enhancing electronic modulation and metabolic stability. This combination improves binding affinity in targeted receptor interactions and supports efficient derivatization under standard coupling conditions.

Application

3-Chloro-5-methoxypicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of halogen and ester functionalities into bioactive heterocycles. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-coupling reactions, while the methoxy group offers orthogonal handle for subsequent derivatization. The compound exhibits excellent bench stability and compatibility with standard synthetic workflows, facilitating efficient access to complex scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.4418
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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