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CS-W001157 4
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(5-Methoxypyridine-2-yl)methanol

  • CAS No. 127978-70-5

  • Cat. No. CS-W006204
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Methoxypyridine-2-yl)methanol|CS-W006204

Structure of 127978-70-5

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General Information

  • CAS No. 127978-70-5
  • Cat. No. CS-W006204
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂
  • Molecular Weight 139.15
  • Synonym(s) (5-Methoxypyridin-2-yl)methanol
  • SMILES OCC1=NC=C(OC)C=C1

Description

This bench-stable (5-methoxypyridine-2-yl)methanol features a pyridine ring bearing a methoxy group at the 5-position and a primary alcohol at the 2-position. The electron-rich aromatic system enhances reactivity in coupling reactions, while the hydroxymethyl functionality enables straightforward derivatization. This compound serves as a versatile building block for pharmaceutical intermediates and functional materials.

Application

(5-Methoxypyridine-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard functional group transformations. Its bench-stable nature and tolerance to diverse reaction conditions facilitate straightforward derivatization for target compound synthesis. The molecule functions effectively in coupling reactions, oxidation processes, and as a precursor in heterocyclic ring construction, supporting scalable workflows in API development.

Synthesis

  • Route1

    References

    • Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh Tetrahedron Letters, 2011 , vol. 52, # 1 p. 122 - 124
  • Route2

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2009/27746 A1, 2009 ; Location in patent: Page/Page column 111 ; WO 2009/027746 A1
  • Route3
    • null|null
      75342-32-4
    • ~64%
    • In-stock
      (5-Methoxypyridine-2-yl)methanol|CS-W006204
      127978-70-5

    References

    • Warner-Lambert Company Patent: US6194437 B1, 2001 ; US 6194437 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.35
  • LogP   0.5825
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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