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Structure of 127561-70-0
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2-Bromo-5-chloropyridin-3-ol features a pyridine core functionalized with bromo and chloro groups at the 2- and 5-positions, respectively, and a hydroxyl group at the 3-position. This trifunctional scaffold enables direct coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and agrochemicals. The electron-deficient ring facilitates nucleophilic substitution, while the phenolic OH enhances solubility and reactivity under standard conditions.
2-Bromo-5-chloropyridin-3-ol serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine center facilitates efficient C–C bond formation, while the chloro and hydroxyl groups offer complementary functionalization sites. Its bench-stable nature and compatibility with standard reaction conditions make it suitable for iterative synthetic sequences in medicinal chemistry and API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: