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CS-W001157 4
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4-Bromo-3-fluoro-2-methylaniline

  • CAS No. 127408-03-1

  • Cat. No. CS-W007186
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-fluoro-2-methylaniline|CS-W007186

Structure of 127408-03-1

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General Information

  • CAS No. 127408-03-1
  • Cat. No. CS-W007186
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrFN
  • Molecular Weight 204.04
  • Synonym(s) 4-Bromo-3-fluoro-2-methyl-phenylamine
  • SMILES NC1=CC=C(Br)C(F)=C1C

Description

4-Bromo-3-fluoro-2-methylaniline delivers a trifunctional aryl scaffold featuring bromine, fluorine, and methyl groups at strategic positions. This electron-deficient aniline derivative enables direct coupling in cross-coupling reactions and integrates readily into complex molecular architectures under standard conditions.

Application

4-Bromo-3-fluoro-2-methylaniline serves as a valuable building block for pharmaceutical and agrochemical synthesis, offering orthogonal reactivity through its bromo, fluoro, and methyl substituents. The molecule enables direct functionalization via palladium-catalyzed cross-coupling and facilitates regioselective electrophilic substitution due to the directing influence of the amino group. Its bench-stable nature and compatibility with common protecting groups support efficient multistep synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.47882
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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