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tert-Butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate

  • CAS No. 1272758-17-4

  • Cat. No. CS-0047425
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate|CS-0047425

Structure of 1272758-17-4

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General Information

  • CAS No. 1272758-17-4
  • Cat. No. CS-0047425
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃NO₃
  • Molecular Weight 253.34
  • Synonym(s) 2-Boc-8-oxo-2-azaspiro[4.5]decane
  • SMILES O=C(N1CCC(CCC2=O)(CC2)C1)OC(C)(C)C

Description

tert-Butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate is a sterically shielded spirocyclic lactam precursor featuring a bench-stable ketone at the C8 position and a protected carboxylic acid ester. This configuration enables direct functionalization at the azaspiro scaffold, facilitating access to complex nitrogen-containing heterocycles in medicinal chemistry campaigns.

Application

tert-Butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to complex nitrogen-containing frameworks. The molecule features a ketone at C8 and a protected carboxylic acid at C2, both of which are amenable to selective transformations. Its robust tert-butyl ester facilitates straightforward deprotection under mild acidic conditions, while the spirocyclic core provides defined stereochemistry and rigidity advantageous in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.7567
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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