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CS-W001157 4
Total: USD 88.00

5-Bromo-2-(piperidin-2-yl)pyridine

  • CAS No. 1270356-25-6

  • Cat. No. CS-0526975
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(piperidin-2-yl)pyridine|CS-0526975

Structure of 1270356-25-6

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General Information

  • CAS No. 1270356-25-6
  • Cat. No. CS-0526975
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃BrN₂
  • Molecular Weight 241.13
  • Synonym(s) 5-Bromo-2-(2-piperidinyl)pyridine
  • SMILES BrC1=CN=C(C2NCCCC2)C=C1

Description

5-Bromo-2-(piperidin-2-yl)pyridine features a brominated pyridine core paired with a piperidinyl substituent, enabling efficient coupling in cross-coupling reactions. The electron-deficient aromatic ring facilitates transition-metal catalysis, while the pendant piperidine offers solubility and coordination potential. This compound serves as a key building block in medicinal chemistry for targeted heterocyclic scaffolds.

Application

5-Bromo-2-(piperidin-2-yl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The bromide functionality offers high reactivity in Suzuki, Stille, and Negishi couplings, while the piperidinyl group provides a basic nitrogen for metal coordination and potential hydrogen bonding in target molecules. Bench-stable and readily purified by column chromatography, it facilitates efficient synthesis of complex pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   2.6587
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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