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CS-W001157 4
Total: USD 88.00

Apixaban impurity 11

  • CAS No. 1267610-26-3

  • Cat. No. CS-M1882
  • Purity≥95%
  • MDL No.MFCD22581648

*For research and further manufacturing use only, not for direct human use.

Apixaban impurity 11|CS-M1882

Structure of 1267610-26-3

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General Information

  • CAS No. 1267610-26-3
  • Cat. No. CS-M1882
  • Purity ≥95%
  • MDL No. MFCD22581648
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₉N₃O₂
  • Molecular Weight 273.34
  • Synonym(s) None
  • SMILES O=C1C(=CCCN1C2=CC=C(N)C=C2)N3CCOCC3

Description

1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone features a conjugated arylamine linked to a reduced pyridinone core bearing a morpholine substituent. This scaffold integrates electron-rich and hydrogen-bonding functionalities, enabling versatile engagement in synthetic transformations and target-directed molecular design.

Application

1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone serves as a versatile scaffold for medicinal chemistry campaigns, enabling the construction of bioactive heterocycles via standard coupling reactions. Its amine functionality facilitates derivatization, while the dihydropyridinone core exhibits favorable solubility and bench stability. Functions effectively in Pd-catalyzed cross-coupling and reductive amination workflows, offering robust utility in API lead optimization.

Synthesis

  • Route1

    References

    • Jiang, Jian'An; Ji, Yafei Synthetic Communications, 2013 ,  vol. 43,  # 1  p. 72 - 79

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.8
  • LogP   1.2216
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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