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Structure of 126728-58-3
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5-Bromo-2-(2,2,2-trifluoroethoxy)pyridine is a fluorinated heterocyclic building block featuring a bromine at the C5 position and a trifluoroethoxy group at C2. This combination imparts enhanced electron-withdrawing character and improved metabolic stability, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The molecule exhibits excellent bench stability and solubility in common organic solvents, facilitating straightforward integration into complex synthetic sequences.
5-Bromo-2-(2,2,2-trifluoroethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and electron-deficient pyridine core. The trifluoroethoxy group enhances metabolic stability and modulates lipophilicity, offering favorable physicochemical properties for drug discovery. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: