Fmoc-DL-Phe-OH

Name: Fmoc-DL-Phe-OH
Brand: ChemScene
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CAS No. 126727-04-6
Cat. No. CS-0149805
Purity≥98%
MDL No.MFCD00112977

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 126727-04-6

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General Information

CAS No. 126727-04-6
Cat. No. CS-0149805
Purity ≥98%
MDL No. MFCD00112977
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₁NO₄
Molecular Weight 387.43
Synonym(s) None
SMILES O=C(O)C(NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CC4=CC=CC=C4

Description

Fmoc-DL-Phe-OH serves as a key building block in solid-phase peptide synthesis, combining the fluorenylmethoxy carbonyl (Fmoc) protecting group with DL-phenylalanine. This derivative enables efficient N-terminal capping and sequential coupling under mild conditions, offering stability during storage and compatibility with standard deprotection protocols.

Application

Fmoc-DL-Phe-OH serves as a key building block in solid-phase peptide synthesis, offering robust protection of the amine group via the fluorenylmethyloxycarbonyl (Fmoc) moiety. The side chain’s phenylalanine functionality provides structural rigidity and hydrophobic character essential for peptide backbone assembly. Its bench-stable nature, compatibility with standard coupling reagents, and ease of purification make it ideal for scalable synthesis of bioactive peptides and protein mimetics.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.221
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-DL-Phe-OH

CAS No. 126727-04-6

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