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CS-W001157 4
Total: USD 88.00

4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine

  • CAS No. 126352-69-0

  • Cat. No. CS-D0070
  • Purity≥98%
  • MDL No.MFCD08273904

*For research and further manufacturing use only, not for direct human use.

4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine|CS-D0070

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General Information

  • CAS No. 126352-69-0
  • Cat. No. CS-D0070
  • Purity ≥98%
  • MDL No. MFCD08273904
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine
  • SMILES C12=CC=NN1CCCN2

Description

4H,5H,6H,7H-Pyrazolo[1,5-a]pyrimidine serves as a core heterocyclic scaffold in medicinal chemistry, offering a rigid, electron-rich framework ideal for kinase inhibition and targeted drug discovery. This planar, nitrogen-dense system integrates readily into bioactive molecules, enhancing binding affinity through π-stacking and hydrogen bonding interactions.

Application

4H,5H,6H,7H-Pyrazolo[1,5-a]pyrimidine serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling the construction of bioactive molecules through well-established functionalization at the 4-, 5-, and 7-positions. Its stability under standard reaction conditions and compatibility with diverse coupling partners facilitate efficient synthesis of potential kinase inhibitors and other pharmaceutical intermediates.

Synthesis

  • Route1
    • 6,7-Dihydropyrazolo[1,5-a]pyrimidin-5(4h)-one|CS-0661917
      29303-21-7
    • ~%
    • In-stock
      4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine|CS-D0070
      126352-69-0

    References

    • US5173485 A1, ;
  • Route2

    References

    • US5173485 A1, ;
  • Route3

    References

    • Bioorganic and Medicinal Chemistry, , vol. 5, # 3 p. 557 - 567

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   0.6987
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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