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CS-W001157 4
Total: USD 88.00

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile

  • CAS No. 1263374-32-8

  • Cat. No. CS-0007929
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile|CS-0007929

Structure of 1263374-32-8

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Description

This aminomethyltetrahydropyran carbonitrile features a pendant nitrile group and a primary amine tethered to a saturated pyran ring, enabling dual functionalization. The rigid tetrahydro-2H-pyran scaffold provides conformational stability, while the amine facilitates coupling reactions. This structure serves as a key intermediate for bioactive molecule synthesis.

Application

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through nucleophilic addition and cyclization reactions. The nitrile group facilitates functionalization via hydrolysis or reduction, while the pendant amine supports conjugation and derivatization. Its tetrahydrofuran ring imparts structural rigidity and favorable solubility, enhancing utility in drug discovery campaigns.

General Information

  • CAS No. 1263374-32-8
  • Cat. No. CS-0007929
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂N₂O
  • Molecular Weight 140.18
  • Synonym(s) 4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile hydrochloride
  • SMILES N#CC1(CN)CCOCC1

Computational Chemistry Data

  • TPSA   59.04
  • LogP   0.26548
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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