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CS-W001157 4
Total: USD 88.00

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile

  • CAS No. 1263374-32-8

  • Cat. No. CS-0007929
  • Molecule weight140.18
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile|CS-0007929

Structure of 1263374-32-8

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General Information

  • CAS No. 1263374-32-8
  • Cat. No. CS-0007929
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂N₂O
  • Molecular Weight 140.18
  • Synonym(s) 4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile hydrochloride
  • SMILES N#CC1(CN)CCOCC1

Description

This aminomethyltetrahydropyran carbonitrile features a pendant nitrile group and a primary amine tethered to a saturated pyran ring, enabling dual functionalization. The rigid tetrahydro-2H-pyran scaffold provides conformational stability, while the amine facilitates coupling reactions. This structure serves as a key intermediate for bioactive molecule synthesis.

Application

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through nucleophilic addition and cyclization reactions. The nitrile group facilitates functionalization via hydrolysis or reduction, while the pendant amine supports conjugation and derivatization. Its tetrahydrofuran ring imparts structural rigidity and favorable solubility, enhancing utility in drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59.04
  • LogP   0.26548
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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