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trans-3-Fluorocyclobutanol

  • CAS No. 1262278-60-3

  • Cat. No. CS-0047784
  • Purity≥95%
  • MDL No.MFCD20489133

*For research and further manufacturing use only, not for direct human use.

trans-3-Fluorocyclobutanol|CS-0047784

Structure of 1262278-60-3

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General Information

  • CAS No. 1262278-60-3
  • Cat. No. CS-0047784
  • Purity ≥95%
  • MDL No. MFCD20489133
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇FO
  • Molecular Weight 90.10
  • Synonym(s) trans-3-Fluorocyclobutanol - F11668
  • SMILES O[C@H]1C[C@H](F)C1

Description

trans-3-Fluorocyclobutanol features a strained cyclobutane ring with a fluorine atom and hydroxyl group in trans configuration, delivering enhanced stability and distinct stereochemical control. This bench-stable, moisture-tolerant reagent integrates readily into synthetic pathways requiring stereoselective functionalization or as a building block in medicinal chemistry.

Application

trans-3-Fluorocyclobutanol serves as a valuable chiral building block in medicinal chemistry, offering a rigid cyclobutane scaffold with defined stereochemistry. Its fluorinated ring system enhances metabolic stability and modulates electronic properties, while the hydroxyl group enables straightforward functionalization via esterification, etherification, or oxidation. The compound exhibits excellent bench stability and facilitates efficient incorporation into bioactive molecules through standard coupling and transformation protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.4792
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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