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CS-W001157 4
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3-Bromopyrazin-2-ol

  • CAS No. 1261634-06-3

  • Cat. No. CS-0161060
  • Purity≥96%
  • MDL No.MFCD18415489

*For research and further manufacturing use only, not for direct human use.

3-Bromopyrazin-2-ol|CS-0161060

Structure of 1261634-06-3

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General Information

  • CAS No. 1261634-06-3
  • Cat. No. CS-0161060
  • Purity ≥96%
  • MDL No. MFCD18415489
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrN₂O
  • Molecular Weight 174.98
  • Synonym(s) 3-Bromo-2(1H)-pyrazinone
  • SMILES OC1=NC=CN=C1Br

Description

3-Bromopyrazin-2-ol features a bromine substituent at the 3-position of a pyrazin-2-ol core, delivering a versatile platform for transition-metal-catalyzed cross-coupling reactions. The molecule combines moderate electron deficiency with a hydrogen-bond-capable hydroxyl group, enabling stable coordination in catalytic systems and facilitating downstream functionalization in synthetic sequences.

Application

3-Bromopyrazin-2-ol serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent and hydrogen-bonding-capable hydroxyl group. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient access to functionalized pyrazine scaffolds relevant to medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.9447
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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