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CS-W001157 4
Total: USD 88.00

2-Chloro-4-(difluoromethyl)pyrimidine

  • CAS No. 1261629-31-5

  • Cat. No. CS-0101632
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-(difluoromethyl)pyrimidine|CS-0101632

Structure of 1261629-31-5

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General Information

  • CAS No. 1261629-31-5
  • Cat. No. CS-0101632
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₂N₂
  • Molecular Weight 164.54
  • Synonym(s) None
  • SMILES FC(C1=NC(Cl)=NC=C1)F

Description

2-Chloro-4-(difluoromethyl)pyrimidine integrates a difluoromethyl group into a pyrimidine scaffold, delivering enhanced metabolic stability and electron-withdrawing character. This configuration supports efficient coupling reactions and facilitates incorporation into bioactive molecules requiring fluorinated alkyl motifs.

Application

2-Chloro-4-(difluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of the difluoromethyl group—a bioisostere of halogens and alkyls—into target molecules. Its chloropyrimidine moiety facilitates nucleophilic substitution and cross-coupling reactions, while the difluoromethyl group enhances metabolic stability and modulates lipophilicity. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it a reliable reagent for constructing pharmaceutically relevant heterocyclic scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.0676
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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