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5-Chloro-2-methoxypyridine-3-sulfonyl chloride

  • CAS No. 1261451-92-6

  • Cat. No. CS-0130959
  • Purity≥97%
  • MDL No.MFCD18411176

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-methoxypyridine-3-sulfonyl chloride|CS-0130959

Structure of 1261451-92-6

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General Information

  • CAS No. 1261451-92-6
  • Cat. No. CS-0130959
  • Purity ≥97%
  • MDL No. MFCD18411176
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂NO₃S
  • Molecular Weight 242.08
  • Synonym(s) None
  • SMILES O=S(C1=CC(Cl)=CN=C1OC)(Cl)=O

Description

5-Chloro-2-methoxypyridine-3-sulfonyl chloride features a reactive sulfonyl chloride group appended to a chlorinated, methoxy-substituted pyridine scaffold. This combination enables direct coupling in nucleophilic substitution reactions, facilitating rapid access to functionalized sulfonamide derivatives under mild conditions. The electron-withdrawing chlorine and methoxy groups enhance electrophilicity at the sulfonyl center while improving solubility in common organic solvents.

Application

5-Chloro-2-methoxypyridine-3-sulfonyl chloride serves as a versatile building block for sulfonamide synthesis, enabling efficient incorporation of pyridyl sulfonamide motifs into bioactive molecules. Its reactivity profile supports straightforward coupling with amines under mild conditions, offering excellent functional group tolerance and bench stability. The molecule facilitates rapid diversification in medicinal chemistry campaigns targeting kinase inhibitors and other heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.26
  • LogP   1.6711
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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