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CS-W001157 4
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2,4,6-Trichloronicotinaldehyde

  • CAS No. 1261269-66-2

  • Cat. No. CS-0047127
  • Purity≥98%
  • MDL No.MFCD17012148

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trichloronicotinaldehyde|CS-0047127

Structure of 1261269-66-2

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General Information

  • CAS No. 1261269-66-2
  • Cat. No. CS-0047127
  • Purity ≥98%
  • MDL No. MFCD17012148
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₃NO
  • Molecular Weight 210.45
  • Synonym(s) 2,4,6-Trichloropyridine-3-carboxaldehyde
  • SMILES O=CC1=C(Cl)C=C(Cl)N=C1Cl

Description

2,4,6-Trichloronicotinaldehyde features a highly electron-deficient pyridine ring flanked by three chlorine substituents, enhancing its reactivity in nucleophilic addition processes. This bench-stable aldehyde integrates readily into synthetic scaffolds requiring strong electrophilic character, particularly in the construction of heterocyclic systems and functionalized aromatic compounds under standard conditions.

Application

2,4,6-Trichloronicotinaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted heterocycles and functionalized pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic addition and condensation reactions, while the aldehyde group offers straightforward derivatization via imine formation or reductive amination. The molecule exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for use in iterative synthesis campaigns and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.8543
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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