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CS-W001157 4
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5-Chloro-1H-pyrido[3,4-b][1,4]oxazin-2(3H)-one

  • CAS No. 1260811-66-2

  • Cat. No. CS-0196639
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Chloro-1H-pyrido[3,4-b][1,4]oxazin-2(3H)-one|CS-0196639

Structure of 1260811-66-2

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Description

5-Chloro-1H-pyrido[3,4-b][1,4]oxazin-2(3H)-one is a heterocyclic scaffold featuring a fused pyridine and oxazine ring system with a chlorine substituent at the 5-position. This electron-deficient core exhibits enhanced stability and solubility in polar solvents, enabling efficient integration into medicinal chemistry campaigns. The lactam functionality supports hydrogen bonding interactions, facilitating target engagement in kinase inhibition studies.

Application

5-Chloro-1H-pyrido[3,4-b][1,4]oxazin-2(3H)-one serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its chlorine substituent enables nucleophilic substitution reactions, facilitating the introduction of diverse functional groups. The fused oxazine core exhibits good bench stability and compatibility with standard coupling protocols, supporting efficient synthesis of complex scaffolds. This compound functions as a key intermediate in the development of bioactive molecules and advanced organic materials.

General Information

  • CAS No. 1260811-66-2
  • Cat. No. CS-0196639
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂O₂
  • Molecular Weight 184.58
  • Synonym(s) 5-CHLORO-1H-PYRIDO[3,4-B][1,4]OXAZIN-2-ONE
  • SMILES O=C1COC2=C(N1)C=CN=C2Cl

Computational Chemistry Data

  • TPSA   51.22
  • LogP   1.0659
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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