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CS-W001157 4
Total: USD 88.00

1-(tert-Butyl)-1H-1,2,3-triazole-4-carboxylic acid

  • CAS No. 1260665-09-5

  • Cat. No. CS-W020488
  • Purity≥97%
  • MDL No.MFCD18250432

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butyl)-1H-1,2,3-triazole-4-carboxylic acid|CS-W020488

Structure of 1260665-09-5

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General Information

  • CAS No. 1260665-09-5
  • Cat. No. CS-W020488
  • Purity ≥97%
  • MDL No. MFCD18250432
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁N₃O₂
  • Molecular Weight 169.18
  • Synonym(s) 1-tert-butyl-1H-1,2,3-triazole-4-carboxylic acid
  • SMILES CC(C)(C)n1cc(nn1)C(O)=O

Description

This bench-stable triazole derivative features a tert-butyl group that enhances solubility and steric protection, while the carboxylic acid moiety enables direct conjugation or derivatization. The electron-deficient triazole ring facilitates efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, making it ideal for bioconjugation and materials functionalization under mild conditions.

Application

1-(tert-Butyl)-1H-1,2,3-triazole-4-carboxylic acid serves as a stable, bench-ready building block for bioactive heterocycles and peptide conjugates. The triazole ring enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the carboxylic acid facilitates amide coupling and derivatization. Its tert-butyl group enhances solubility and simplifies purification, making it ideal for modular synthesis in medicinal chemistry and chemical biology workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   68.01
  • LogP   0.7313
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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