6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine

Name: 6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine
Brand: ChemScene
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CAS No. 1260656-87-8
Cat. No. CS-0443411
Molecule weight267.00
Purity≥97%
MDL No.None

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6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine|CS-0443411

Structure of 1260656-87-8

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General Information

CAS No. 1260656-87-8
Cat. No. CS-0443411
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₂BrF₃N₂O
Molecular Weight 267.00
Synonym(s) 6-bromo-2-(trifluoromethyl)-[1,3]oxazolo[4,5-b]pyridine
SMILES C1=C(C=NC2=C1OC(=N2)C(F)(F)F)Br

Description

6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine is a heterocyclic building block featuring a bromo group at the 6-position and a trifluoromethyl substituent at the 2-position. This combination imparts enhanced electron-withdrawing character and improved metabolic stability, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The scaffold serves as a key intermediate in the synthesis of functionalized pharmaceuticals and agrochemicals.

Application

6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine serves as a versatile building block for the synthesis of functionalized heterocycles in medicinal chemistry and materials science. The bromo group enables palladium-catalyzed cross-coupling reactions, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. Its oxazolopyridine core provides a rigid, electron-deficient scaffold with favorable solubility and bench stability, facilitating efficient purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 38.92
LogP 3.0041
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Oxazole compounds

Key Words

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6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine

CAS No. 1260656-87-8

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