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6-Methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid

  • CAS No. 1260383-27-4

  • Cat. No. CS-0443847
  • Molecule weight192.17
  • Purity≥96%
  • MDL No.MFCD18381025

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid|CS-0443847

Structure of 1260383-27-4

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General Information

  • CAS No. 1260383-27-4
  • Cat. No. CS-0443847
  • Purity ≥96%
  • MDL No. MFCD18381025
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₃
  • Molecular Weight 192.17
  • Synonym(s) 6-Methoxy-5-azaindole-2-carboxylic acid
  • SMILES COC1=NC=C2C=C(C(=O)O)NC2=C1

Description

6-Methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid features a fused heterocyclic core with orthogonal functional groups enabling direct integration into bioactive scaffolds. The methoxy substituent enhances solubility and modulates electron density, while the carboxylic acid moiety provides a handle for amide coupling and derivatization under standard conditions.

Application

6-Methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling direct incorporation into bioactive scaffolds. The carboxylic acid functionality facilitates amide coupling and esterification, while the methoxy group provides moderate electron-donating character and enhanced solubility. Bench-stable and compatible with standard peptide coupling protocols, it functions effectively in multi-step syntheses requiring functional group tolerance and predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.21
  • LogP   1.2697
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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