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Structure of 1260381-44-9
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4-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile features a fused heterocyclic core with complementary electron-withdrawing groups: a fluorine atom at the 4-position and a nitrile group at the 5-position. This combination imparts enhanced electrophilicity and metabolic stability, enabling efficient coupling in cross-coupling reactions. The molecule exhibits favorable solubility in common organic solvents and maintains integrity under standard bench conditions. It serves as a key scaffold for developing bioactive compounds in medicinal chemistry.
4-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused pyrrole-pyridine scaffolds. The nitrile group facilitates downstream transformations such as amidation and reduction, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard coupling reactions, it functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and nucleophilic substitution protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: