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CS-W001157 4
Total: USD 88.00

4-(4-Chlorophenyl)picolinic acid

  • CAS No. 1258612-04-2

  • Cat. No. CS-0188063
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(4-Chlorophenyl)picolinic acid|CS-0188063

Structure of 1258612-04-2

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General Information

  • CAS No. 1258612-04-2
  • Cat. No. CS-0188063
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈ClNO₂
  • Molecular Weight 233.65
  • Synonym(s) None
  • SMILES C1=C(C=CC(=C1)Cl)C2=CC(=NC=C2)C(=O)O

Description

4-(4-Chlorophenyl)picolinic acid features a conjugated aryl-pyridine scaffold with a para-chlorophenyl group enhancing electron-withdrawing character. This rigid, planar structure supports π-stacking interactions and facilitates metal coordination in supramolecular assemblies. The carboxylic acid moiety enables salt formation and conjugation with biomolecules.

Application

4-(4-Chlorophenyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its structure combines a picolinic acid core with a para-chlorophenyl substituent, offering enhanced metabolic stability and favorable electronic properties. The carboxylic acid group facilitates coupling reactions, while the chlorophenyl moiety supports further functionalization via cross-coupling or nucleophilic substitution. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   3.1002
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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