tert-Butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride

Name: tert-Butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 1258001-18-1
Cat. No. CS-0121766
Purity≥98%
MDL No.MFCD20921814

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride|CS-0121766

Structure of 1258001-18-1

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General Information

CAS No. 1258001-18-1
Cat. No. CS-0121766
Purity ≥98%
MDL No. MFCD20921814
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₂ClN₃O₂
Molecular Weight 251.75
Synonym(s) 4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride
SMILES O=C(N1CCC(NN)CC1)OC(C)(C)C.[H]Cl

Description

tert-Butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride delivers a bench-stable, moisture-tolerant hydrazine handle for late-stage functionalization. This derivative features a protected piperidine core paired with a reactive hydrazino group, enabling efficient coupling in diverse synthetic sequences. Its hydrochloride salt enhances solubility and handling, streamlining integration into complex molecular architectures.

Application

tert-Butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride serves as a versatile building block for the synthesis of hydrazine-containing heterocycles and bioactive molecules. The hydrazinyl group enables efficient cyclization reactions, while the tert-butyl carbamate offers stability and orthogonal deprotection under mild acidic conditions. This reagent facilitates the construction of piperazine and imidazole scaffolds commonly found in medicinal chemistry campaigns, with excellent functional group tolerance and ease of handling in standard synthetic workflows.

Synthesis

Route1
- 79099-07-3
- ~59%
- 1258001-19-2
- In-stock
  
  1258001-18-1
References
- PFIZER INC.; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton, Jr. Patent: WO2012/69948 A1, 2012 ; Location in patent: Page/Page column 54 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 67.59
LogP 1.271
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Hydrazine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride

CAS No. 1258001-18-1

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