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CS-W001157 4
Total: USD 88.00

2-Bromo-5,8-dioxaspiro[3.4]octane

  • CAS No. 1257996-82-9

  • Cat. No. CS-0052000
  • Purity≥97%
  • MDL No.MFCD20637976

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5,8-dioxaspiro[3.4]octane|CS-0052000

Structure of 1257996-82-9

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General Information

  • CAS No. 1257996-82-9
  • Cat. No. CS-0052000
  • Purity ≥97%
  • MDL No. MFCD20637976
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉BrO₂
  • Molecular Weight 193.04
  • Synonym(s) 2-bromo-5,8-dioxa-spiro[3.4]octane
  • SMILES BrC1CC2(C1)OCCO2

Description

This spirocyclic bromide features a rigid, electron-deficient core that enables selective functionalization in complex molecule assembly. The dioxaspiro framework enhances stability and solubility in polar aprotic solvents, facilitating efficient coupling reactions under mild conditions.

Application

2-Bromo-5,8-dioxaspiro[3.4]octane serves as a versatile spirocyclic building block for the synthesis of complex heterocyclic systems. Its rigid bicyclic framework and bromine substituent enable selective functionalization via palladium-catalyzed cross-coupling reactions. The molecule exhibits good bench stability and facilitates efficient access to spiro-ether scaffolds relevant in medicinal chemistry due to its defined stereochemistry and compatibility with standard synthetic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   1.2868
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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