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Structure of 1256921-67-1
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Methyl 6-bromo-3-chloropyrazine-2-carboxylate is a halogenated pyrazine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromo group at C6 enables palladium-catalyzed coupling, while the chloro substituent at C3 offers orthogonal reactivity. This dual-halogenation pattern facilitates sequential derivatization in complex molecule synthesis, particularly in medicinal chemistry and agrochemical development.
Methyl 6-bromo-3-chloropyrazine-2-carboxylate serves as a versatile heterocyclic building block for the synthesis of pharmaceutical intermediates and agrochemical scaffolds. Its orthogonal halogenation pattern enables sequential cross-coupling reactions, including Suzuki and Stille couplings, with high chemoselectivity. The ester functionality supports further derivatization, while the pyrazine core provides metabolic stability and favorable physicochemical properties in drug discovery applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: