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Methyl 3-fluoro-5-hydroxypicolinate

  • CAS No. 1256836-96-0

  • Cat. No. CS-0049099
  • Molecule weight171.13
  • Purity≥98%
  • MDL No.MFCD18257413

*For research and further manufacturing use only, not for direct human use.

Methyl 3-fluoro-5-hydroxypicolinate|CS-0049099

Structure of 1256836-96-0

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General Information

  • CAS No. 1256836-96-0
  • Cat. No. CS-0049099
  • Purity ≥98%
  • MDL No. MFCD18257413
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₃
  • Molecular Weight 171.13
  • Synonym(s) methyl 3-fluoro-5-hydroxypyridine-2-carboxylate
  • SMILES COC(=O)C1=NC=C(O)C=C1F

Description

Methyl 3-fluoro-5-hydroxypicolinate features a strategically positioned fluorine atom and hydroxyl group on the picolinate scaffold, enabling selective functionalization in synthetic sequences. This electron-deficient heterocycle integrates readily into bioactive molecule frameworks, offering enhanced metabolic stability and tailored solubility under standard conditions.

Application

Methyl 3-fluoro-5-hydroxypicolinate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. The ortho-fluoro and hydroxyl groups provide complementary reactivity for palladium-catalyzed couplings and regioselective derivatization. Bench-stable and readily purified by crystallization, it functions effectively in late-stage functionalization and API intermediate synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7129
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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