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Structure of 1256822-94-2
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2-Bromo-6-fluoropyridin-3-ol features a pyridin-3-ol core bearing bromo and fluoro substituents at the 2- and 6-positions, respectively. This electron-deficient heterocycle integrates readily into cross-coupling reactions, offering enhanced regioselectivity in late-stage functionalization. The phenolic hydroxyl group enables direct derivatization or coordination in catalytic systems. Bench-stable under standard conditions, it serves as a key building block for pharmaceutical intermediates and agrochemicals.
2-Bromo-6-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct Suzuki-Miyaura and Buchwald-Hartwig coupling reactions due to its orthogonal halogen reactivity. The fluorine and hydroxyl groups provide enhanced metabolic stability and hydrogen-bonding capacity, while the bromine facilitates palladium-catalyzed transformations. Bench-stable and readily purified by recrystallization, it functions efficiently in the construction of substituted pyridine scaffolds common in kinase inhibitors and CNS-targeted therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: