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Structure of 1256822-25-9
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3-Fluoro-5-methylpicolinaldehyde features a fluorinated pyridine core with a methyl group at the 5-position and an aldehyde at the 2-position. This electron-deficient heteroaryl aldehyde integrates readily into cross-coupling reactions and serves as a key intermediate in medicinal chemistry, particularly for targeted kinase inhibitors and bioactive molecule scaffolds.
3-Fluoro-5-methylpicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via standard condensation and cyclization reactions. Its ortho-fluorinated pyridine core provides enhanced metabolic stability and modulates electronic properties, while the aldehyde functionality facilitates efficient derivatization through reductive amination, Schiff base formation, and Ugi-type multicomponent reactions. Bench-stable and readily purified by distillation or chromatography, it functions reliably in scale-up processes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H317-H319
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Precautionary Statements : P261-P264-P272-P280-P302+P352-P363-P501
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Lot numbers can be found on the outside label of a product: