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3-Fluoro-5-methylpicolinaldehyde

  • CAS No. 1256822-25-9

  • Cat. No. CS-0527410
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-5-methylpicolinaldehyde|CS-0527410

Structure of 1256822-25-9

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General Information

  • CAS No. 1256822-25-9
  • Cat. No. CS-0527410
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) 2-pyridinecarboxaldehyde,3-fluoro-5-methyl
  • SMILES O=CC1=NC=C(C)C=C1F

Description

3-Fluoro-5-methylpicolinaldehyde features a fluorinated pyridine core with a methyl group at the 5-position and an aldehyde at the 2-position. This electron-deficient heteroaryl aldehyde integrates readily into cross-coupling reactions and serves as a key intermediate in medicinal chemistry, particularly for targeted kinase inhibitors and bioactive molecule scaffolds.

Application

3-Fluoro-5-methylpicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via standard condensation and cyclization reactions. Its ortho-fluorinated pyridine core provides enhanced metabolic stability and modulates electronic properties, while the aldehyde functionality facilitates efficient derivatization through reductive amination, Schiff base formation, and Ugi-type multicomponent reactions. Bench-stable and readily purified by distillation or chromatography, it functions reliably in scale-up processes.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P363-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.34162
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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