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6-Bromo-3-chloro-2-methoxypyridine

  • CAS No. 1256810-58-8

  • Cat. No. CS-0150234
  • Purity≥95%
  • MDL No.MFCD18257583

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3-chloro-2-methoxypyridine|CS-0150234

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General Information

  • CAS No. 1256810-58-8
  • Cat. No. CS-0150234
  • Purity ≥95%
  • MDL No. MFCD18257583
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrClNO
  • Molecular Weight 222.47
  • Synonym(s) CJXSBRMPNXLISI-UHFFFAOYSA-N
  • SMILES COC1=NC(=CC=C1Cl)Br

Description

6-Bromo-3-chloro-2-methoxypyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromo group at C6 enables palladium-catalyzed transformations, while the chloro substituent at C3 offers orthogonal reactivity. The methoxy group at C2 enhances solubility and modulates electronic properties, facilitating efficient incorporation into complex heterocyclic architectures under standard conditions.

Application

6-Bromo-3-chloro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates efficient C–C bond formation, while the chloro and methoxy functionalities offer orthogonal functionalization potential. Its bench-stable nature and clean purification profile support scalable synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.5061
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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