Methyl 6-amino-5-fluoronicotinate

Name: Methyl 6-amino-5-fluoronicotinate
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CAS No. 1256792-42-3
Cat. No. CS-0149402
Molecule weightNone
Purity≥97%
MDL No.MFCD18250741

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Methyl 6-amino-5-fluoronicotinate|CS-0149402

Structure of 1256792-42-3

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General Information

CAS No. 1256792-42-3
Cat. No. CS-0149402
Purity ≥97%
MDL No. MFCD18250741
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇FN₂O₂
Molecular Weight None
Synonym(s) methyl 6-amino-5-fluoropyridine-3-carboxylate
SMILES O=C(C1=CC(F)=C(N)N=C1)OC

Description

Methyl 6-amino-5-fluoronicotinate features a fluorinated pyridine core with strategically positioned amino and ester functionalities. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced metabolic stability and targeted bioavailability in kinase inhibitor development.

Application

Methyl 6-amino-5-fluoronicotinate serves as a versatile building block in medicinal chemistry, enabling direct access to fluorinated pyridine scaffolds common in kinase inhibitors and CNS-targeted therapeutics. The amino and ester functionalities offer orthogonal reactivity—facilitating amide coupling, electrophilic substitution, or directed metalation—while the methyl ester supports facile hydrolysis or transformation into carboxylic acid derivatives. Bench-stable and readily purified by recrystallization, it functions efficiently in standard coupling protocols and multistep syntheses.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 65.21
LogP 0.5895
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 6-amino-5-fluoronicotinate

CAS No. 1256792-42-3

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