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CS-W001157 4
Total: USD 88.00

3-Bromo-6-fluoro-2-methoxypyridine

  • CAS No. 1256789-63-5

  • Cat. No. CS-0614411
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-fluoro-2-methoxypyridine|CS-0614411

Structure of 1256789-63-5

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General Information

  • CAS No. 1256789-63-5
  • Cat. No. CS-0614411
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) None
  • SMILES COC1=NC(F)=CC=C1Br

Description

3-Bromo-6-fluoro-2-methoxypyridine features a strategically positioned bromo and fluoro substituent on a pyridine core, enabling selective cross-coupling reactions. The methoxy group enhances solubility and modulates electronic properties, while the halogen pattern supports palladium-catalyzed transformations under standard conditions. This bench-stable reagent integrates efficiently into complex molecular architectures.

Application

3-Bromo-6-fluoro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine and methoxy substituents provide tunable electronic effects and steric control. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing functionalized pyridine scaffolds in API development and agrochemical synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.9918
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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