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CS-W001157 4
Total: USD 88.00

2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid

  • CAS No. 1256584-73-2

  • Cat. No. CS-M1475
  • Purity≥98%
  • MDL No.MFCD22571222

*For research and further manufacturing use only, not for direct human use.

2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid|CS-M1475

Structure of 1256584-73-2

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General Information

  • CAS No. 1256584-73-2
  • Cat. No. CS-M1475
  • Purity ≥98%
  • MDL No. MFCD22571222
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅IO₂
  • Molecular Weight 318.15
  • Synonym(s) Alectinib Impurity 14
  • SMILES CCC1=CC=C(C(C)(C(O)=O)C)C=C1I

Description

This boronate moiety integrates seamlessly into Suzuki-Miyaura coupling workflows, offering enhanced reactivity under standard conditions. The para-nitro group facilitates efficient cross-coupling with arylboronic acids, enabling rapid access to complex biaryl architectures in synthetic organic chemistry.

Application

2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its sterically hindered α,α-dimethyl carboxylic acid moiety provides excellent bench stability and facilitates straightforward purification. The iodide group exhibits high reactivity in Suzuki, Stille, and Negishi couplings, making this compound ideal for medicinal chemistry campaigns and API intermediate synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   3.2158
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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