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CS-W001157 4
Total: USD 88.00

(3-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid

  • CAS No. 1256345-88-6

  • Cat. No. CS-0030231
  • Purity≥96%
  • MDL No.MFCD12026733

*For research and further manufacturing use only, not for direct human use.

(3-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid|CS-0030231

Structure of 1256345-88-6

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General Information

  • CAS No. 1256345-88-6
  • Cat. No. CS-0030231
  • Purity ≥96%
  • MDL No. MFCD12026733
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BF₃O₄
  • Molecular Weight 235.95
  • Synonym(s) 3-Methoxy-5-(trifluoromethoxy)phenylboronic acid
  • SMILES FC(F)(F)OC1=CC(OC)=CC(B(O)O)=C1

Description

This boronic acid features a methoxy-substituted aryl ring paired with a trifluoromethoxy group, delivering enhanced stability and solubility in polar solvents. The electron-withdrawing trifluoromethoxy moiety modulates reactivity, enabling efficient Suzuki-Miyaura coupling under mild conditions. Ideal for constructing complex pharmaceutical scaffolds and functionalized heterocycles.

Application

(3-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability, compatibility with diverse functional groups, and predictable reactivity make it ideal for constructing complex aryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   58.92
  • LogP   0.2736
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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