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CS-W001157 4
Total: USD 88.00

4-Bromo-1-(difluoromethyl)-2-methoxybenzene

  • CAS No. 1254034-35-9

  • Cat. No. CS-0443272
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-(difluoromethyl)-2-methoxybenzene|CS-0443272

Structure of 1254034-35-9

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General Information

  • CAS No. 1254034-35-9
  • Cat. No. CS-0443272
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrF₂O
  • Molecular Weight 237.04
  • Synonym(s) 4-Bromo-1-difluoromethyl-2-methoxy-benzene
  • SMILES COC1=C(C(F)F)C=CC(Br)=C1

Description

This difluoromethyl-substituted aryl bromide features a methoxy group at the ortho position, enabling seamless coupling in cross-coupling reactions. The electron-withdrawing difluoromethyl moiety enhances reactivity while maintaining bench stability under standard conditions.

Application

4-Bromo-1-(difluoromethyl)-2-methoxybenzene serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable aryl bromide functionality. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the methoxy substituent provides orthogonal reactivity. This compound exhibits excellent bench stability and facilitates efficient synthesis of fluorinated heterocycles and bioactive scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.3953
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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