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CS-W001157 4
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Tert-butyl 4-(5-aminoisoxazol-3-yl)piperidine-1-carboxylate

  • CAS No. 1253789-76-2

  • Cat. No. CS-0272821
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 4-(5-aminoisoxazol-3-yl)piperidine-1-carboxylate|CS-0272821

Structure of 1253789-76-2

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General Information

  • CAS No. 1253789-76-2
  • Cat. No. CS-0272821
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁N₃O₃
  • Molecular Weight 267.32
  • Synonym(s) 2,4-DICHLORO-8-QUINAZOLINECARBONITRILE
  • SMILES CC(C)(C)OC(=O)N1CCC(CC1)C2=NOC(=C2)N

Description

Tert-butyl 4-(5-aminoisoxazol-3-yl)piperidine-1-carboxylate integrates a bioactive aminoisoxazole motif with a conformationally constrained piperidine scaffold. This bench-stable, moisture-tolerant building block facilitates efficient access to novel heterocyclic pharmacophores through straightforward deprotection and coupling strategies.

Application

Tert-butyl 4-(5-aminoisoxazol-3-yl)piperidine-1-carboxylate serves as a versatile building block for constructing bioactive heterocycles, enabling direct functionalization at the piperidine nitrogen and the aminoisoxazole ring. The tert-butyl carbamate group offers bench stability and facilitates straightforward deprotection under mild acidic conditions. It functions effectively in standard coupling reactions and supports orthogonal transformations, making it well-suited for medicinal chemistry campaigns targeting CNS-directed therapeutics and kinase inhibitors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   81.59
  • LogP   2.3713
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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