(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-morpholinopropanoic acid

Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-morpholinopropanoic acid
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CAS No. 1251903-85-1
Cat. No. CS-0443244
Molecule weight396.44
Purity≥98%
MDL No.None

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(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-morpholinopropanoic acid|CS-0443244

Structure of 1251903-85-1

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General Information

CAS No. 1251903-85-1
Cat. No. CS-0443244
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₂₄N₂O₅
Molecular Weight 396.44
Synonym(s) Fmoc-3-(1-Morpholinyl)-L-Ala-OH
SMILES C1CN(C[C@@H](C(=O)O)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)CCO1

Description

This fluoren-9-ylmethoxycarbonyl-protected amino acid derivative features a chiral morpholino side chain, enabling efficient incorporation into peptide sequences. The Fmoc group ensures orthogonal protection during solid-phase synthesis, while the morpholinopropanoic backbone offers enhanced solubility and stability under standard coupling conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-morpholinopropanoic acid serves as a versatile chiral building block for peptide synthesis, enabling the incorporation of morpholinoproline-like motifs with high enantiocontrol. The Fmoc group provides excellent stability and orthogonal deprotection under mild basic conditions, while the morpholino side chain offers enhanced solubility and hydrogen-bonding capacity. This derivative facilitates efficient coupling reactions and is well-suited for solid-phase and solution-phase peptide extensions.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 88.1
LogP 2.3105
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-morpholinopropanoic acid

CAS No. 1251903-85-1

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